Transneuronal and Transcellular Transport Mechanisms That Nanoparticle Formulations Must Exploit for Peptide CNS Delivery via the Nasal Route
Marcus Oyelaran
Marcus Oyelaran
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Nose-to-Brain Nanoparticle Platform Differentiation Across Reward Circuit and Dementia Indications
Nanoparticle design must match delivery to brain circuit, not just cross the barrier.
Marcus Oyelaran
Injection Anxiety and Dose Titration Failures as Structural Drivers of Early GLP-1 Abandonment
Needle anxiety and titration nausea drive early GLP-1 dropout.
Marcus Oyelaran
Nanoparticle Scale-Up Challenges From Lab Bench to GMP Manufacturing
Particle properties shift unpredictably when equipment scales up.
Marcus Oyelaran
Bioavailability Benchmarks for Intranasal Peptide Formulations
Plasma bioavailability fails to measure what intranasal brain-targeted peptides actually achieve.
Marcus Oyelaran
Lipid Nanoparticles vs Polymeric Nanoparticles for Delivering Peptides to the CNS
Lipid nanoparticles excel at endosomal escape; polymeric ones protect peptides better in transit.
Marcus Oyelaran